Minocycline
Pharmacological action
Antibiotic tetracycline. Has bacteriostatic action due to suppression of protein synthesis by reversible binding to the 30S ribosomal subunit of susceptible organisms.
Active against gram-positive bacteria: Staphyloccocus aureus, Streptococcus spp., Nocardia spp., Listeria spp., Bacillus anthracis; Gram-negative bacteria: Neisseria meningitidis, Bartonella bacilliformis, Vibrio cholerae, Esherichia coli, Klebsiella spp., Shigella spp., Acinetobacter spp. , Haemophilus spp.; anaerobic bacteria: Clostridium spp., Bacteroides spp.
Minocycline is also active against Mycobacterium spp. (Including Mycobacterium leprae), Chlamydia spp., Ureaplasma urealyticum, Treponema pallidum.
Statement
Acne, nokardioz, leprosy (as part of combination therapy), infectious and inflammatory diseases caused by pathogens susceptible to minocycline (including pneumonia, bronchitis, empyema, angina, cholecystitis, pyelonephritis, intestinal infections, endocarditis, endometritis, prostatitis , syphilis, gonorrhea, brucellosis, rickettsiosis, purulent soft tissue infection, osteomyelitis, trachoma).
Minocycline dosage
When administered daily dose for adults is 100-200 mg.
For children older than 8 years the dose is 4 mg / kg, then 2 mg / kg every 12 hours
Minocycline Side effect
Probably: vestibular disorders (dizziness, unsteadiness), pigmentation of the skin and mucous membranes, hepatotoxic effect, nausea, vomiting, candidiasis.
Contraindications
Liver dysfunction, child age 8 years, increased sensitivity to tetracycline.
Application of pregnancy and breastfeeding
Minocycline crosses the placental barrier and is excreted in breast milk.
Do not apply in the second half of pregnancy and lactation, as Minocycline causes discoloration of teeth, enamel hypoplasia, and dysplasia of bones of the skeleton of the fetus and child.
Cautions
When taken with milk and dairy products violated removals minocycline.
Minocycline causes discoloration of teeth, enamel hypoplasia, and dysplasia of bones of the skeleton of the fetus and child, so that minocycline does not apply in children younger than 8 years.